Table 5.
Studies outlining the effects of supplementing dietary arachidonic acid on changes in plasma/serum phospholipid arachidonic acid level
| Author, (reference) | Study design | Subjects | Diet length | AA source, amount supplemented (g/d) | Δ AA (%) change | Comments |
|---|---|---|---|---|---|---|
| Sinclair [54] | Parallel intervention | N = 4 | 7 days | White meat/eggs (0.50) | 52 (p < 0.05) | Consumed AA rich, low fat diet |
| Ishikura [55] | Double-blind crossover | N = 25 | 1 month | SUNTGA40S capsules (0.72) | 27 (p < 0.05) | Derived from Mortierella alpina |
| Theis [45] | Randomized, double-blind, parallel intervention | N = 48 | 12 weeks | ARASCO (0.68) | 85 (p < 0.05) | Derived from Mortierella alpina |
| Kusmoto [56] | Double-blind intervention | N = 12 | 4 weeks | SUNTGA40S (0.84) | 45 (p < 0.05) | Derived from Mortierella alpina |
| Nelson [57] | Single blind crossover intervention | N = 10 | 50 days | ARASCO (1.49) | 85 (p < 0.05) | Had 65 day washout period. Derived from Mortierella alpina |
| Seyberth [58] | Single blind intervention | N = 4 | 2-3 weeks, depending upon subject | Capsules, AA ethyl ester (6.00) | 136 (p < 0.05) | Averaged from all 4 subjects |
Percent change (±) from baseline in AA that is significant is identified with (p < 0.05). Percent change (±) from baseline in AA that is not significant is denoted by N.S.
Abbreviations: AA, arachidonic acid