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. 2011 Jul 8;6(7):e21960. doi: 10.1371/journal.pone.0021960

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Hoffmann et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In vitro MSC growth in terms of the number of cells (top) and mean population radius (bottom) for three representative culturing experiments (dash-dotted) and the mean (solid) standard deviation (dotted) of 10 differently random-seeded simulations. Saturating exponential population growth and linear radius expansion are characteristics of MSC culture using Petri dishes. The mean population radius is confined to about 300 because of the experimental image dimensions. The experimental image frame is used for the evaluation of all simulation results of this subsection (MSC on plain substrates). Model cells are confined to a spherical area safely containing the image frame. This mimics the experimental effect of restricted expansion due to neighboring cell cultures (the effect depends on seeding density; an example is shown in Figure S1).

Inline graphic — In vitro MSC growth in terms of the number of cells (top) and mean population radius (bottom) for three representative culturing experiments (dash-dotted) and the mean (solid) standard deviation (dotted) of 10 differently random-seeded simulations. Saturating exponential population growth and linear radius expansion are characteristics of MSC culture using Petri dishes. The mean population radius is confined to about 300 because of the experimental image dimensions. The experimental image frame is used for the evaluation of all simulation results of this subsection (MSC on plain substrates). Model cells are confined to a spherical area safely containing the image frame. This mimics the experimental effect of restricted expansion due to neighboring cell cultures (the effect depends on seeding density; an example is shown in Figure S1).