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. 2011 Jul 8;6(7):e21960. doi: 10.1371/journal.pone.0021960

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Hoffmann et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Order parameter during culture days 3 to 13. Down-regulation of the mean cell volume growth rate from 1200 to 0 occurs linearly in the range between and nearest neighbors (see Modeling methods section G) with being set to 3∶4 (red), 4∶5 (blue), 5∶6 (green) and (orange) (i.e. down-regulation disabled). Mean values (solid) standard deviation (dotted) of 10 differently random-seeded simulations. Cell-cell alignment increases almost independently of cell growth during early cell expansion (>day 4) in the experiments (top) as well as the model (bottom). Subsequently, it may be destroyed again depending on how insensitive cell growth is with regard to cell density (i.e. the number of neighboring cells). The insets show simulation snap shots for regulation 3∶4 (red) and (orange) both at day 9 of cell culture.

Inline graphic — Order parameter during culture days 3 to 13. Down-regulation of the mean cell volume growth rate from 1200 to 0 occurs linearly in the range between and nearest neighbors (see Modeling methods section G) with being set to 3∶4 (red), 4∶5 (blue), 5∶6 (green) and (orange) (i.e. down-regulation disabled). Mean values (solid) standard deviation (dotted) of 10 differently random-seeded simulations. Cell-cell alignment increases almost independently of cell growth during early cell expansion (>day 4) in the experiments (top) as well as the model (bottom). Subsequently, it may be destroyed again depending on how insensitive cell growth is with regard to cell density (i.e. the number of neighboring cells). The insets show simulation snap shots for regulation 3∶4 (red) and (orange) both at day 9 of cell culture.