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. Author manuscript; available in PMC: 2011 Sep 23.
Published in final edited form as: Sci Transl Med. 2011 Mar 23;3(75):75ra26. doi: 10.1126/scitranslmed.3002003

Fig. 2.

Fig. 2

Acquired genetic amplifications in drug-resistant lung tumors. Amplification of MET and EGFR genes was observed in biopsies of tumors from patients who had acquired resistance to EGFR TKIs. Shown are FISH analyses that detect the MET gene (green), EGFR gene (red), and the control CEP7 gene (aqua). (A) The pretreatment specimen from patient 19 (left panel) shows a normal MET copy number but significant EGFR amplification; the drug-resistant posttreatment specimen (right panel) from the same patient exhibits acquired MET amplification but normal EGFR copy number. (B) Patient 13 demonstrated an acquired EGFR amplification in the drug-resistant posttreatment specimen (right panel) compared to the pretreatment specimen (left panel).