Table 1.
GeneOntology categories targeted by PIAs at 6h in H157 cells
| OVEREXPRESSION | |||||
|---|---|---|---|---|---|
| GO CATEGORY | TOTAL GENES | CHANGED GENES | ENRICHMENT | LOG10(p) | FDR |
| GO:0050789_regulation_of_biological_process | 2170 | 24 | 2.1105 | −4.5343 | 0.0000 |
| GO:0050791_regulation_of_physiological_process | 1998 | 22 | 2.1012 | −4.0073 | 0.0000 |
| GO:0051244_regulation_of_cellular_physiological_process | 1873 | 21 | 2.1395 | −3.8992 | 0.0033 |
| GO:0050794_regulation_of_cellular_process | 1963 | 21 | 2.0414 | −3.5890 | 0.0050 |
| GO:0006915_apoptosis | 356 | 8 | 4.2882 | −3.3683 | 0.0080 |
| GO:0012501_programmed_cell_death | 358 | 8 | 4.2642 | −3.3519 | 0.0067 |
| GO:0008219_cell_death | 377 | 8 | 4.0493 | −3.2021 | 0.0086 |
| GO:0016265_death | 379 | 8 | 4.0280 | −3.1868 | 0.0075 |
| GO:0009611_response_to_wounding | 324 | 7 | 4.1228 | −2.8881 | 0.0300 |
| GO:0048519_negative_regulation_of_biological_process | 464 | 8 | 3.2901 | −2.6194 | 0.0256 |
| GO:0051243_negative_regulation_of_cellular_physiological_process | 396 | 7 | 3.3732 | −2.3934 | 0.0310 |
| GO:0007050_cell_cycle_arrest | 42 | 3 | 13.6304 | −2.8766 | 0.0270 |
| GO:0000074_regulation_of_cell_cycle | 327 | 7 | 4.0849 | −2.8648 | 0.0245 |
| GO:0007049_cell_cycle | 504 | 8 | 3.0290 | −2.3968 | 0.0326 |
| GO:0042330_taxis | 109 | 4 | 7.0028 | −2.6160 | 0.0228 |
| GO:0006935_chemotaxis | 109 | 4 | 7.0028 | −2.6160 | 0.0228 |
| GO:0048514_blood_vessel_morphogenesis | 46 | 3 | 12.4451 | −2.7616 | 0.0233 |
| GO:0001525_angiogenesis | 46 | 3 | 12.4451 | −2.7616 | 0.0233 |
| GO:0001568_blood_vessel_development | 46 | 3 | 12.4451 | −2.7616 | 0.0233 |
| GO:0001944_vasculature_development | 46 | 3 | 12.4451 | −2.7616 | 0.0233 |
| UNDEREXPRESSION | |||||
| GO:0006261_DNA-dependent_DNA_replication | 58 | 3 | 26.3207 | −3.7506 | 0.0400 |