Table 2.
Time dependent changes in gene ontology caused by PIA6 treatment in H157 cells
| GO CATEGORY | Changed/Total genes (FDR) | ||
|---|---|---|---|
| OVEREXPRESSION | 2h | 6h | 12h |
| GO:0001944_vasculature_development | 10/46 (0.0227) | ||
| GO:0001568_blood_vessel_development | 10/46 (0.0227) | ||
| GO:0048514_blood_vessel_morphogenesis | 10/46 (0.0227) | ||
| GO:0001525_angiogenesis | 10/46 (0.0227) | ||
| GO:0050878_regulation_of_body_fluids | 16/98 (0.0238) | ||
| GO:0007599_hemostasis | 15/87 (0.0209) | ||
| GO:0042060_wound_healing | 15/87 (0.0209) | ||
| GO:0009611_response_to_wounding | 41/324 (0.0200) | ||
| GO:0050817_coagulation | 15/81 (0.0150) | ||
| GO:0007596_blood_coagulation | 15/81 (0.0150) | ||
| GO:0006412_protein_biosynthesis | 47/371 (0.0200) | ||
| GO:0009059_macromolecule_biosynthesis | 49/409 (0.0133) | ||
| GO:0006915_apoptosis | 8/356 (0.030) | 43/356 (0.0129) | |
| GO:0012501_programmed_cell_death | 4/358 (0.05) | 8/358 (0.015) | 43/358 (0.0111) |
| GO:0008219_cell_death | 4/377 (0.04) | 8/377 (0.020) | 45/377 (0.0200) |
| GO:0016265_death | 4/379 (0.03) | 8/379 (0.015) | 45/379 (0.0125) |
| UNDEREXPRESSION | |||
| GO:0006261_DNA-dependent_DNA_replication | 3/58 (0.0100) | 8/58 (0.0000) | |
| GO:0006260_DNA_replication | 3/113 (0.0118) | 14/113 (0.0000) | |
| GO:0006259_DNA_metabolism | 5/365 (0.0075) | 23/365 (0.0000) | |
| GO:0006270_DNA_replication_initiation | 5/14 (0.0000) | ||
| GO:0006310_DNA_recombination | 5/48 (0.0076) | ||
| GO:0006139_nucleobase__nucleoside__nucleotide_and_nucleic_acid_metabolism | 49/1892 (0.0000) | ||
| GO:0043283_biopolymer_metabolism | 29/998 (0.0042) | ||
| GO:0006281_DNA_repair | 13/142 (0.0000) | ||
| GO:0006974_response_to_DNA_damage_stimulus | 14/157 (0.0000) | ||
| GO:0009719_response_to_endogenous_stimulus | 14/166 (0.0000) | ||
| GO:0006950_response_to_stress | 24/755 (0.0045) | ||
| GO:0007049_cell_cycle | 6/504 (0.0050) | 25/504 (0.0000) | |
| GO:0000074_regulation_of_cell_cycle | 5/327 (0.0100) | 14/327 (0.0031) | |
| GO:0051244_regulation_of_cellular_physiological_process | 10/1873 (0.0071) | 42/1873 (0.0368) | |
| GO:0000279_M_phase | 9/149 (0.0038) | ||
| GO:0051301_cell_division | 8/119 (0.0033) | ||
| GO:0000910_cytokinesis | 8/119 (0.0033) | ||
| GO:0000278_mitotic_cell_cycle | 10/177 (0.0040) | ||
| GO:0000086_G2_M_transition_of_mitotic_cell_cycle | 4/37 (0.0245) | ||
| GO:0000087_M_phase_of_mitotic_cell_cycle | 7/121 (0.0248) | ||
| GO:0007067_mitosis | 7/119 (0.0258) | ||