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. Author manuscript; available in PMC: 2012 Jul 18.
Published in final edited form as: Adv Drug Deliv Rev. 2010 Nov 29;63(8):610–615. doi: 10.1016/j.addr.2010.11.001

Fig. 2. Regulation of cell migration and invasion by FAK through multiple signaling pathways.

Fig. 2

Several mechanisms by which FAK regulates cell migration and invasion are depicted here. These include serving as a scaffold for Src phosphorylation of p130cas, direct phosphorylation of Grb7 in a PI3K dependent manner and phosphorylation of N-WASP to regulate its cytoplasmic retention to control cell migration in a variety of cells, and mediating phosphorylation of endophilin A2 by Src to regulate surface expression of MT1-MMP in cancer cells.