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Leptin receptor mRNA was lower in Old rats, and this was prevented in the Old+L rats. The p85 regulatory subunit of phosphatidylinositol 3 kinase (PI3K) was significantly higher in both Old and Old+L groups. *P < 0.01 vs. Old; #P < 0.05 vs. Old + L-158,809; @P < 0.001 vs. others.
