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. 2011 Jul;13(7):620–632. doi: 10.1593/neo.11134

Figure 8.

Figure 8

CED-mediated distribution of ACCA in immunodeficient rat brains. (A) Coronal brain sections, 1 mm in thickness, were obtained from animals that received 40 mM ACCA for 14 days through CED to the CPu region (non-tumor-bearing rats). Sections were weighed and processed for HPLC-MS analysis for ACCA concentration per slice. Slice 0 indicates cannulation point; slices A1–A3, anterior slices at 1-mm intervals from the cannulation point; slices P1–P3, posterior slices at 1-mm intervals from the cannulation point. (B) The ACCA concentrations (micrograms per gram of wet weight of brain) recorded were 0.195 ± 0.27 (A3), 0.0385 ± 0.54 (A2), 1.16 ± 0.06 (A1), 5.11 ± 0.24 (0), 7.21 ± 1.06 (P1), 2.52 ± 0.01 (P2), 0.595 ± 0.17 (P3).