FIG 2 .
(A) First trial of moxifloxacin-plus-rifampin 7/7-day versus 5/7-day regimens. The AUC exposures in the symbol keys are the free AUC24 hs that were infused into that particular hollow fiber system experimental arm on the days that the drugs were administered. (B) Second trial of moxifloxacin-plus-rifampin 7/7-day versus 5/7-day regimens. The AUC exposures in the figure legends are the free AUC24 hs that were infused into that particular hollow fiber system experimental arm on the days that the drugs were administered. There is re-growth between day 23 and day 28, specifically in the lowest exposure group (arm E) in the experimental arm where the drugs were administered 5/7days. There was a 2.25 Log10 (CFU/ml) difference between arms B and E, attributable to difference in administration schedule and weekly drug exposures. In arm E colonies recovered had a wild-type MIC for rifampin (0.03 mg/L), but increased 4-fold for moxifloxacin (0.25 to 1.0 mg/L).