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Paradoxical stimulation of UFC (A) and 17OHS (B) in patients with PPNAD (closed circles) versus those with MMAD (triangles) and solitary cortisol-producing adenomas (squares) during the course of Liddle’s test. C. 50% increase of UFCs on day#6 of the test detects more than 70% of the patients with PPNAD versus other cortisol producing tumors of the adrenal cortex. D. PPNADs express synaptohysin within the cortical nodules, an unexpected feature for a cortical lesion.
