Table 7.

High levels of leukocytes are inactivated in platelet components by the INTERCEPT Blood System

Assay system	Evidence of inactivation
In vitro
Limiting dilution assay	>5.4 log10 reduction of viable T cells
DNA modification	Approximately one amotosalen adduct per 83 base pairs
Polymerase chain reaction	Amplification inhibited by amotosalen – DNA adducts
Cytokine synthesis	Elimination of IL-8, IL-1β synthesis during storage
In vivo
Murine transfusion model	Prevention of TA-GVHD in a murine parent to F1 transfusion model