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Degradation of S-303 molecule in RBCs.
The degradation kinetics of S-303 in RBCs (SAG-M RBC + treatment solution) were measured by an HPLC method for concentrations greater than 1 μmol/l and an LC/MS/MS method for lower concentrations. The limit of quantitation for the LC/MS/MS assay is 0.75 nmol/l. The residual levels of S-303 are shown without the volume exchange step. The level of S-303 after the pathogen inactivation process is below the limit of quantitation.
