Table 1.

Features of different SD plasma products

Type of plasma	Source and quality	Pool size	Inactivation time and temperature	Removal of abnormal prion binding protein (PrPSc)	Final product
Octaplas (Austria)	high-quality apheresis or recovered plasma*	380 l (630 apheresis units or 1,520 recovered units)	4 h at 30 °C (1% TNBP + 1% Triton X-100)	2.5 log reduction of PrPSc as a result of the SD manufacturing process	200 ml frozen in plastic bags
OctaplasLG (Austria)	high-quality apheresis or recovered plasma*	380 l (630 apheresis units or 1,520 recovered units)	1–1.5 h at 30 °C (1% TNBP + 1% Triton X-100)	> 5 log reduction of PrPSc after additional affinity chromatography with PrPSc binding ligand	200 ml frozen in plastic bags
Plasmasafe (Italy)	high-quality apheresis or recovered plasma*	380 l (630 apheresis units or 1,520 recovered units)	4 h at 30 °C (1% TNBP + 1% Triton X-100)	not documented, but probably similar to Octaplas	200 ml frozen in plastic bags
Plasma viro-atténué Solvant détergent (France)	high-quality apheresis plasma	60 l (100 apheresis units)	4 h at 30 °C (1% TNBP + 1% Triton X-100)	not documented, but probably similar to Octaplas	200 ml frozen in plastic bags
Bioplasma FDP (South Africa)	high-quality recovered plasma	200 l	4 h at 30 °C (1% TNBP + 1% Triton X-100)	not documented, but probably similar to Octaplas	50 and 200 ml lyophilized in glass bottles
PLAS+SD (USA)	recovered plasma frozen next day	650 l (2,500 recovered units)	4 h at 30 °C (1% TNBP + 1% Triton X-100)	not documented, but probably similar to Octaplas	200 ml frozen in plastic bags (produced from 1998 to 2002)
‘Mini-pool’ (for blood bank application in resource limited countries)	recovered plasma	5–10 l	4 h at 31 °C (1% TNBP + 1% Triton X-45)	unknown	depending upon local practice
			or
			4 h at 37 °C (2% TNBP)

^*Except Octaplas specially produced for Ireland where recovered US plasma of similar quality as that for PLAS+SD was used.