Table 2. Temperature and Chaperonin-Induced Modulation of BdpA Folding Pathway^a.

model (temperature)	TS1 and TS2	TS1 and TS2 none or weak	TS1	TS2
bulk (3.0)b	21%	27%	29%	23%
bulk (2.82)*	23%	24%	30%	23%
small (2.82)*	18%	31%	30%	21%

^aThe modulation is shown by the percentage of four kinds of TSE structures for which TS1 and TS2 are well formed, or none of them, or TS1 only, or TS2 only. TSE structures were parsed as TS1 or TS2 well-formed if the number of long-range side-chain contacts within TS1 or TS2, native or non-native, was above an average from the entire simulation (measured in the bulk and given temperature). The average number of contact threshold values were 9.3 ± 3.1* (TS1), 6.1 ± 2.5 (TS2) at T = 3.0 and 10.6 ± 3.3* (TS1), 6.4 ± 2.5 (TS2) at T = 2.82 (*note that the TS1 threshold is much larger at lower temperature).

^bStructure examples are shown in Figure 2B.