Fig. 4.

Phylogenetic comparison reveals high conservation of sequences required for signal-responsive inclusion of LEF1 exon 6. Clustal W alignment of sequences surrounding LEF1 exon 6 with the corresponding sequences from armadillo (Dasypus novemcinctus) (aLEF1), dog (Canis lupus familiaris) (dLEF1), cow (Bos taurus) (cLEF1), rat (Rattus norvegicus) (rLEF1), mouse (Mus musculus) (mLEF1), and human (Homo sapiens) (LEF1). Nucleotides that are absolutely conserved are indicated by an asterisk. The elements are indicated by colors as follows: blue, USE60 (encompasses the 3′ splice site [3′ss]); red, exon 6; orange, 5′ splice site; green, DSE120 (highly conserved elements in DSE120 are in darker green).