Table 4.

Overrepresented functions and categories in SNP-associated genes^a

Categoryb	Description	No. of genes in the genomec	No. of SNP-associated genesd	P valuee
GO:0009405	Pathogenesis	2	2	4.46e−4
GO:0044403	Symbiosis, encompassing mutualism through parasitism	2	2	4.46e−4
GO:0044419	Interspecies interaction between organisms	2	2	4.46e−4
GO:0016616	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	23	4	1.19e−3
GO:0050661	NADP or NADPH binding	11	3	1.33e−3
GO:0016614	Oxidoreductase activity, acting on the CH-OH group of donors	24	4	1.41e−3
GO:0051704	Multiorganism process	5	2	4.28e−3
GO:0016491	Oxidoreductase activity	147	8	1.09e−2
GO:0055086	Nucleobase, nucleoside, and nucleotide metabolic processes	66	5	1.20e−2
GO:0046483	Heterocycle metabolic process	105	6	2.21e−2
GO:0006753	Nucleoside phosphate metabolic process	53	4	2.48e−2
GO:0009117	Nucleotide metabolic process	53	4	2.48e−2
GO:0048037	Cofactor binding	83	5	2.97e−2
GO:0034641	Cellular nitrogen compound metabolic process	119	6	3.81e−2
GO:0006007	Glucose catabolic process	15	2	3.92e−2
GO:0019320	Hexose catabolic process	15	2	3.92e−2
GO:0046365	Monosaccharide catabolic process	15	2	3.92e−2
GO:0044275	Cellular carbohydrate catabolic process	16	2	4.42e−2
GO:0046164	Alcohol catabolic process	16	2	4.42e−2
GO:0006807	Nitrogen compound metabolic process	456	15	4.53e−2
GO:0044248	Cellular catabolic process	38	3	4.56e−2

^aCategories of SNP-associated genes were analyzed using the hypergeometric distribution against the background of all genes.

^bGene ontology (GO) functional category.

^cNumber of genes in the M13220 reference genome belonging to this category (2,108 total genes in the genome).

^dNumber of SNP-associated genes belonging to this category (45 total SNP-associated genes).

^eP value for the hypergeometric testing for enrichment of the GO category.