Table 1.
Percentages of surviving mice at E17.5, P1 to P10, and P21 to P28
| Cross and genotype | % of surviving mice (mean ± SEM)a |
||
|---|---|---|---|
| Embryo | P1–P10 | 3–4 wk | |
| Brg1f/f × smMHC-Cre+/− Brg1f/+ | |||
| Brg1f/+ smMHC-Cre−/− (WT) | 20.8 ± 2.5 | 22.7 ± 2.7 | 27.7 ± 3.0 |
| Brg1f/+ smMHC-Cre−/+ (smBrg1 heterozygous) | 26.1 ± 4.6 | 31.3 ± 3.8 | 29.2 ± 3.0 |
| Brg1f/− smMHC-Cre−/− (global Brg1 heterozygous) | 23.2 ± 4.6 | 31.2 ± 3.3 | 25.6 ± 3.8 |
| Brg1f/− smMHC-Cre−/+ (smBrg1 KO/global Brg1 heterozygous) | 29.9 ± 5.1 | 15.9 ± 2.3* | 17.9 ± 2.6* |
| Total no. of mice | 87 | 222 | 278 |
| Brg1f/f Brm−/− × smMHC-Cre+/− Brg1f/+ Brm−/− | |||
| Brg1f/+ smMHC-Cre−/− Brm−/− (Brm KO) | 19.3 ± 4.9 | 27.7 ± 2.7 | 43.2 ± 8.7 |
| Brg1f/+ smMHC-Cre−/+ Brm−/− (smBrg heterozygous/Brm KO) | 24.9 ± 7.3 | 29.9 ± 3.3 | 38.3 ± 11.6 |
| Brg1f/− smMHC-Cre−/− Brm−/− (global Brg1 heterozygous/Brm KO) | 25.8 ± 4.5 | 22.7 ± 3.2 | 18.6 ± 5.9 |
| Brg1f/− smMHC-Cre−/+ Brm−/− (smBrg1 KO/global Brg1 heterozygous/Brm KO) | 30.1 ± 6.3 | 18.1 ± 2.6* | 0 |
| Total no. of mice | 56 | 263 | 47 |
| Brg1f/f Brm−/− × smMHC-Cre+/− Brg1f/+ | |||
| Brg1f/+ smMHC-Cre−/− Brm+/− (WT Brg1/Brm heterozygous) | 28.9 ± 5.4 | ||
| Brg1f/+ smMHC-Cre−/+ Brm+/− (smBrg heterozygous/Brm heterozygous) | 31.2 ± 5.1 | ||
| Brg1f/− smMHC-Cre−/− Brm+/− (global Brg1 heterozygous/Brm heterozygous) | 24.3 ± 4.1 | ||
| Brg1f/− smMHC-Cre−/+ Brm+/− (smBrg1 KO/global Brg1 heterozygous/Brm heterozygous) | 15.7 ± 3.1* | ||
| Total no. of mice | 109 | ||
a
The mean percentage of mice, per litter, representing each of the indicated genotypes when genotyping was performed at E17.5, neonatal day P1 to P10, or 3 to 4 weeks after birth. The mice analyzed at 3 to 4 weeks are distinct from those genotyped at P1 to P10. *, significantly different from the expected 25% (1-sample t test).