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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: J Immunol. 2011 May 4;186(12):7187–7194. doi: 10.4049/jimmunol.1100412

Figure 3. Nlrp6-deficient mice have increased susceptibility to chemically-induced colitis and inflammation-induced tumorigenesis.

Figure 3

A, Ten age- and sex-matched wildtype (WT) and Nlrp6-deficient mice were treated with 7 days of 3.5% DSS and survival of mice was assessed. Data was analyzed by log-rank test. B, Age and sex-matched Nlrp6−/− (N=26 mice) and wildtype (N=25 mice) mice, were treated with AOM intraperitoneally followed by three cycles of 2% DSS. Three weeks after the last cycle of DSS, mice were sacrificed and tumors grossly counted with a stereomicroscope. Photographs are representative of tumors within the distal rectum of Nlrp6−/− and wildtype mice. Data is represented by means +/− S.E.M. *p <1 ×10-7 by Student’s t-test.