Table 3. Antituberculosis drug-induced hepatotoxicity in children treated for tuberculosis.

Drugs	INH Dosage mg/kg	Studies	N	Liver function tests abnormal	Symptoms or signs of liver disease
INH	6–10	2	218	4/50 (8.0%)	Jaundice in 1 (0.46%)
INH & other agents	<10–20	13	3053	49/443 (11.1%)	Jaundice 12 (0.39%)
INH & RMP	8–15	3	224	32/224 (14.3%)	Symptoms of ADIH 3 (1.3%). Jaundice 2 (0.89%).
INH & RMP	10–20	7	453	64/413 (15.5%)	Jaundice 52 (11.5%).
INH & RMP and other agents	5–14	16	2714	141/1762 (8.0%)	Symptoms of ADIH 35 (1.3%). Jaundice 3 (0.11%)
INH & RMP and other agents	10–20	9	2322	139/1406 (9.8%)	Symptoms of ADIH 6 (0.26%). Jaundice 5 (0.22%)
		50	8984	380/3855 (9.9%)	Symptoms of ADIH 32 (0.36%) Jaundice 75 (0.91%)

Tuberculous meningitis
INH, RMP and other agents	10–15	4	259	Not routinely determined	Other drugs substituted 23 (8.9%). Jaundice 26 (10.0%)
INH, RMP and other agents	10–20	11	458	174/329 (52.9%)	Jaundice 46 (10.0%)
		15	717	174/329 (52.9%)	Jaundice 72/717 (10.04%)

INH, isoniazid; RMP, rifampicin.