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. 2011 Jun 16;3(2):e17. doi: 10.4081/pr.2011.e17

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©Copyright A. Cao et al., 2011

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Current hemoglobin switching model. Globin gene activation is dependent upon concentration of Klf1. In the fetal stage of erythroid development or at low Klf1 concentration, weakly expressed Bcl11A can not repress γ-globin genes and Klf1 preferentially interacts with the γ-globin genes that are stimulated upon recruitment of LCR elements. In the adult stage or at high Klf1 concentration, overexpressed Bcl11A represses γ-globin genes and Klf1 binds preferentially the β-globin genes that are stimulated upon recruitment of the LCR (Inactive genes are grayed, active genes are in light green). LCR, Locus control region; KLF, Krueppel-like factor; Bcl11A: B cell lymphoma 11°.