Table 4.

Percentage of patients correctly completing each item of the checklists on Day 1 and Day 7

(a) Breezhaler checklist	Day 1	Day 7	(b) HandiHaler checklist	Day 1	Day 7
1. Pull off cap	100.0	100.0	1. Open the cap	98.8	97.5
2. Open mouthpiece	98.8	100.0	2. Open mouthpiece	96.3	97.5
3. Remove capsule from blister pack	98.8	100.0	3. Remove capsule from blister pack	93.8	97.5
4. Insert capsule in the inhaler	100.0	100.0	4. Insert capsule in the inhaler	98.8	100.0
5. Close inhaler – click heard	98.8	98.8	5. Close inhaler – click heard	98.8	98.8
			6. Pierce the capsule	95.1	98.8
6. Was the mouthpiece facing upwards?	96.3	97.5	7. Pierced once only	92.7	91.4
7. Pierce the capsule	97.5	96.3	8. Click/piercing noise heard by assessor	92.7	100.0
8. Pierced once only	95.1	90.0	9. Was inhaler held upright?	89.0	88.9
9. Click/piercing noise heard	93.8	95.0
10. Were both buttons pressed simultaneously?	95.1	97.5
11. Release buttons	90.2	97.5	10. Release button	88.9	96.3
12. Were buttons fully released before inhalation?a	92.7	96.3	11. Was button fully released before inhalation?a	87.7	98.8
13. Breathe out – not into mouthpiecea	84.1	85.2	12. Breathe out – not into mouthpiecea	80.2	81.3
			13. Was inhaler held horizontally during inhalation?	85.2	95.0
14. Inhale the medicine rapidly and steadily	87.8	93.8	14. Inhale the medicine slowly and deeply	88.9	93.8
15. Were the air inlets unobstructed by fingers?	92.7	91.4	15. Were the air inlets unobstructed by fingers?	91.4	95.0
16. Audible whirring noise	82.9	91.4
17. Hold breath for as long as is comfortable	84.1	77.8	16. Hold breath for as long as is comfortable	75.3	86.3
18. Check upon whether capsule has been fully emptied	80.5	77.8
19. If residue is remaining in capsule, did patient close inhaler and repeat steps 13–18	82.1	80.8	17. Did the patient repeat steps 12–16 to ensure full dose was taken from capsule?	69.1	83.8
20. Open inhaler, remove capsule, close inhaler and replace cap	95.1	96.3	18. Open cap, remove capsule, close and replace cap	88.9	97.5
21. Was capsule pierced at both ends?	93.9	98.8	19. Was capsule pierced at both ends?	95.1	96.3

^aNote: Prespecified as a particularly critical step.