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Summary of effect of nAChR agonists on L-dopa induced AIMs in rats with a partial and near-complete striatal dopamine lesion. Nicotine and nAChR drugs more effectively reduce L-dopa-induced AIMs with partial nigrostriatal damage.
| Drug | Drug-induced decrease in L-dopa-induced AIMs | |
|---|---|---|
| Partial lesion | Near-complete lesion | |
| Varenicline | ~40% | ~10% |
| A-85380 | ~50% | ~20% |
| Nicotine | 50–70%b | 20–40%a |
From Bordia et al., 2010; unpublished observations.
From Bordia et al., 2008
