Figure 6.

Activation of TRPA1 by DEP-EtOH in mouse DRG neurons. DRG were treated with 50 µM AITC or the DEP-EtOH extract prepared from a 2.3 mg/mL suspension in the presence or absence of the TRPA1 antagonist HC-030031 (50 µM). Data are represented as percent maximum response as elicited by KCl (50 mM). Each data point is the mean ± SEM response from DRG cultures of four separate animals. *Indicates significant inhibition by HC-030031 (p<0.05 using Student’s t-test).