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. Author manuscript; available in PMC: 2012 Jun 20.
Published in final edited form as: Chem Res Toxicol. 2011 May 25;24(6):950–959. doi: 10.1021/tx200123z

Table 3.

Activation of TRPA1 by DEP-derived chemicals, or structurally similar analogues, isolated from an ethanol extract of DEP by HPLC and identified by GC-EIMS.

Name Structure TRPA1 Activity
% AITC
trans,trans-1,4-Diphenyl-1,3-butadiene graphic file with name nihms299888t1.jpg N.D.
4-Phenyl-1,2-dihydronaphthalene graphic file with name nihms299888t2.jpg 14 ± 3*
[(3E)-1-Phenyl-1,3-pentadienyl]benzene graphic file with name nihms299888t3.jpg 73 ± 27*
(1-Phenyl-1-pentenyl)benzene graphic file with name nihms299888t4.jpg 26 ± 3*
[(2Z)-1-Methyl-3-phenyl-2-butenyl]benzene graphic file with name nihms299888t5.jpg 6 ± 8
[(2Z)-3-Phenyl-2-butenyl]benzene graphic file with name nihms299888t6.jpg 5 ± 2*
4-Hydroxybenzyl alcohol graphic file with name nihms299888t7.jpg N.D
2-Hydroxybenzyl alcohol graphic file with name nihms299888t8.jpg N.D
3,5-Ditert-butylphenol graphic file with name nihms299888t9.jpg 87 ± 26*
2,4-Ditert-butylphenol graphic file with name nihms299888t10.jpg 89 ± 11*
Dibutylphthalate graphic file with name nihms299888t11.jpg 2 ± 2

All treatments were at 250 µM and are reported as the % response relative to the positive control AITC (150µM).

*

Indicates significant induction of calcium flux compared to non-transfected controls using Student’s t-test, p<0.05 (n=3).