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. Author manuscript; available in PMC: 2011 Jul 12.
Published in final edited form as: Eur J Haematol. 2009 Jan;82(1):1–12. doi: 10.1111/j.1600-0609.2008.01171.x

Table 2.

Differential diagnostic of WM (20)

Differential diagnostic Characteristic features
SMZL CD22, CD11c overexpressed with SMZL, whereas CD25 was more common in WM(88% vs. 44%).
Loss of 7q along with +3q and +5q in SMZL
IgM-MGUS No morphologic evidence of bone marrow infiltration at trephine biopsy however possible detectable bone marrow clonal B cells by flow cytometry
6q-suggested marker to distinguish WM from IgM-MGUS
IgM-MM Pure plasma cell morphology in myeloma and presence of lytic bone lesions in myeloma
B-cell CLL Lymphocytes typically small and mature, without visible nucleoli, and smudge cells
Lymphocytes in CLL are positive for CD5 and CD23
Mantle cell lymphoma Bone marrow infiltration by monomorphous small-medium lymphoid cells, with irregular nuclei and presence of involves lymphonodes, and extranodal sites such as gastro-intestinal tract and spleen and t(11;14) (q13;q32)