Table 2.

Breast cancer: fertility preservation procedures depending on hormone receptor status and oncological treatment plan in women with a medium to high risk of amenorrhoea

	Adjuvant situation (fertility preservation after surgery and before chemotherapy)		Neoadjuvant situation (fertility preservation before chemotherapy and before surgery)
	Hormone receptor negative	Hormone receptor positive	Hormone receptor negative	Hormone receptor positive
Hormonal stimulation and cryopreservation of unfertilised and fertilised oocytes	+	(+)	(+)	−
		(± combination with letrozole)	(± combination with letrozole)
Cryopreservation of ovarian tissue	+	+	+	+
Combination of hormonal stimulation and cryopreservation of oocytes and ovarian tissue	+	(+)	(+)	−
		(± combination with letrozole)	(± combination with letrozole)
GnRH-agonists	+	(−)	+	(−)