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Hodgkin’s lymphoma—Chemotherapy-associated amenorrhoea rate (A = adriamycin; B = bleomycin; C = cyclophosphamide; E = etoposide; O = oncovin; P = procarbazine and prednisone V = vinblastine) modified according to [40])
| Age (years) | Chemotherapy | Rate of amenorrhoea (%) |
|---|---|---|
| ≥30 | 2 × ABVD (HD 7, arm B) | 0 |
| 5.6 | ||
| <30 | ||
| ≥30 | 2 × COPP/ABVD (HD 8) | 12.2 |
| 3.5 | ||
| <30 | ||
| ≥30 | 4 × COPP/ABVD (HD 9 A) | 53.3 |
| 23.5 | ||
| <30 | ||
| ≥30 | 8 × BEACOPP (HD 9, arm B) | 42.1 |
| 11.8 | ||
| <30 | ||
| ≥30 | 8 BEACOPP escalated (HD 9, Arm C) | 70.4 |
| 40.4 | ||
| <30 |
