Fig. 3.

DNA methylation profile of CTS2 in II2 and a control individual, as determined by bisulfite genomic sequencing. Each line corresponds to a single template DNA molecule cloned; each circle corresponds to a CpG dinucleotide. Filled circles designate methylated cytosine; open circles, unmethylated cytosines. The CpGs included in the CTS2 are indicated. The individual analysed as control carries a 1.4 kb B5-B3 deletion on its paternal chromosome. Results very similar to II2 were obtained from III1 (not shown).