Table 7.

Clinicopathological differences in patient data among three time periods

Variable	Period 1 1994–1998, % (n = 18)	Period 2 1999–2003, % (n = 29)	Period 3 2004–2008, % (n = 36)	Kruskal–Wallis, P-value
Male	56	52	64	0.603
Age < 60 years	44	31	50	0.303
Percutaneous transhepatic biliary drainage	12	48	21	0.076
Endoscopic retrograde cholangiopancreatography	88	52	60	0.058
Trisectionectomy	61	72	64	0.786
Portal vein resection	33	41	39	0.859
Hepatic artery resection	6	10	8	0.407
Operation time, mins, median (range)	330 (240–480)	395 (165–540)	390 (120–630)	0.835
Blood transfusion	89	69	33	<0.001
Complications	56	61	71	0.470
Elevated neutrophil : lymphocyte ratio	33	57	33	0.191
Postoperative mortality	11	7	6	0.727
Postoperative stay, days, median (range)	17 (8–24)	17 (10–59)	23 (5–137)	0.171
Size > 25 mm	50	56	43	0.657
Well differentiated	50	52	36	0.399
Microscopic direct vascular invasion	56	36	61	0.123
Perineural invasion	88	93	86	0.696
T-stage ½	56	68	43	0.143
Positive lymph nodes (N1)	50	57	61	0.741
Distant metastasis (M1)	28	10	3	0.022
R0 resection	39	52	44	0.679
Median survival, months	11	17	31	0.716

Data in bold are significant at P < 0.05.