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. Author manuscript; available in PMC: 2011 Jul 12.
Published in final edited form as: Adv Cancer Res. 2008;100:35–83. doi: 10.1016/S0065-230X(08)00002-X

Table III.

Axl as a Therapeutic Target

Inhibitor Outcome Reference
Axl-DN construct Reduced glioblastoma growth and invasiveness in vitro and in vivo; Increased overall survival after orthotopic implantation of glioblastoma cells containing Axl-DN Vajkoczy et al. (2006)
shRNA Axl construct Decreased growth of breast carcinoma tumors in an ectopic xenograft model Holland et al. (2005)
Axl small molecule inhibitor (MP470) May inhibit in vitro Axl kinase activity with limited selectivity; cytotoxic to gastrointestinal stromal tumor cells in vitro Mahadevan et al. (2007)