Table 2.
Increase in LOD/HLOD scores in subsets of families and significance values based on 1000 simulations
Marker | Subset | Cytogenetic position | Model | LOD (ϕ) stratified sample | LOD (ϕ) unstratified sample | ΔLOD (p) | HLOD (á, ϕ) stratified group | HLOD (á, ϕ) unstratified group | ΔHLOD (p) |
---|---|---|---|---|---|---|---|---|---|
D1S1609 | H1(−) | 1q44 | BD | 3.01 (0.01) | 0.15 (0.3) | 2.86 (0.025) | 3.01 (1, 0.01) | 1.34 (0.25, 0) | 1.67 (0.102) |
D1S1679 | H1(+) | 1q22 | NR | 5.69 (0.01) | 5.77 (0.05) | −0.08 (0.137) | 5.82 (0.85, 0) | 5.80 (0.95, 0.05) | 0.02 (0.176) |
D1S1677 | H1(+) | 1q22 | NR | 3.65 (0.05) | 2.15 (0.1) | 1.50 (0.037) | 3.65 (1, 0.05) | 2.26 (0.8, 0.1) | 1.39 (0.035) |
D3S3045 | H1(+) | 3q13.12 | NR | 3.30 (0.1) | 2.11 (0.2) | 1.19 (0.064) | 3.30 (1, 0.1) | 2.40 (0.75, 0.1) | 0.90 (0.086) |
P-values <0.05 are in bold.