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. Author manuscript; available in PMC: 2011 Jul 12.
Published in final edited form as: Biol Psychiatry. 2006 Apr 21;60(2):152–162. doi: 10.1016/j.biopsych.2006.02.015

Table 1.

Meta-Analysis Site and Sample Information

Sample Investigators/
Sample Ethnicity		 Published?
Family-Based Samples
Case-Control Samples
Sample Collection and Genotyping
Associationa Families n Trios Cases Control
Subjects		 Diagnostic
Criteria		 Genotyping
Method
1 Nimgaonkar/
Chowdari		 Yh 151 463 151 151 127 DSM-IV SNaPshot
Caucasianc G-G-G-G
2 Nimgaonkar/
Deshpande/Thelma		 Yh 269 912 269 0 0 DSM-IV FP
Indian A-T-A-A
3 NIMHd Y 39 146 39 0 0 DSM-IIIR SNaPshot
Caucasian A-T-A-A
4 Williams/
O’Donovan/Owen		 Yi 0 0 0 711 708 DSM-IV FP/RFLPg
Caucasian x-T-x-A
5 Vallada/Cordeiro Yl 49 147 49 271 576 DSM-IV FP
Braziliane x-G-x-G
6 Kendler/Chen Yk 267 1337 46 0 0 DSM-IV FP-TDI
Caucasian G-G-G-G
7 Brzustowicz/
Bassett		 N 25 75 25 0 0 DSM-IIIR Pyrosequencing
Caucasian
8 Collier/Li N 609 2,036 609 609 157 DSM-IIIR CASP
Chinese
9 Kirov/
O’Donovan/Owen		 N 293 905 293 0 0 DSM-IV FP
Caucasian
10 Sobell/Heston N 182 609 82 612 704 DSM-IIIR Taqman
Caucasianf
11 Gill/Morris/Corvin Yj 0 0 0 299 645 DSM-IIIR SNaPshot
Caucasianc G-G-G-Gb
12 Weinberger/
Egan/Straub		 N 276 1180 153 255 242 DSM-IV Taqman
Caucasian
13 Collier/
Feng/St.Clair		 N 0 0 0 580 596 DSM-IIIR CASP
Caucasian
Total 2,160 7,810 1,716 3,488 3,755

RFLP, restriction fragment length polymorphisms; SNP, single nucleotide polymorphism; RGS4, regulator of G-protein signaling 4; SCZ, schizophrenia; NIMH, National Institute of Mental Health; FP, fluorescence polarization; FP-TDI, fluorescence polarization with template directed dye terminator incorporation; CASP, competitive allele specific polymerase chain reaction.

a

Reported associations and associated alleles for SNPs 1– 4 –7–18, respectively, at RGS4.

b

Reported in narrow SCZ subtype.

c

Samples 1 and 11 have been expanded from initial populations for the current analyses.

d

National Institute of Mental Health Collaborative Genetics Initiative.

e

Due to known ethnic admixture within population, ethnicity for some individuals is unclear. All individuals recoded as “Brazilian.”

f

The majority of the population is Caucasian, however individuals of other ethnicities exist and have been identified for analyses.

g

FP assay used to type SNPs 4, 7, 18. RFLP method used for SNP1.

h

Described in Chowdari et al 2002.

i

Described in Williams et al 2004b.

j

Described in Morris et al 2004.

k

Described in Chen et al 2004.

l

Described in Cordeiro et al 2005.