Table 3.

Family-Based Analyses: Haplotype Transmission Results

Sample	Families	Overtransmitted Haplotype/p-Value	Global Test p-Valueb
1	151	G-G-G-G/.20	.307
2	269	A-T-A-A/.055	.021
3	39	A-T-A-A/.0006	.002
5	49	G-G-G-G/.1	.393
6	267	G-G-G-G/.01a	.007
7c	25	G-G-G-G/.78	.469
8c	609	A-T-A-A/.43	.214
9c	293	A-T-A-A/.2	.49
10c	182	G-G-G-G/.19	.193
12c	276	A-T-A-A/.13a	.396

Family-based transmission distortion for the two most common haplotypes in individual samples. Results show overtransmitted haplotype and corresponding individual haplotype p-value.

FBAT, family-based association test; TDT, transmission disequilibrium test.

^ap-values are results of haplotype analyses (FBAT software) with extended pedigrees. All other p-values are single haplotype TDT results.

^bGlobal p-values for individual samples are whole marker results generated using the FBAT permutation test (100,000 permutations).

^cUnpublished sample.