Table 2.
Demographic Data and Method of Risk Determination of ARVC in 48 Subjects at High Risk Who Received an ICD and 58 Matched Control Subjects From 11 Families With ARVC Linked to 3p25
| Demographic Parameters |
ICD Cohort
|
Control Cohort
|
ICD Cohort M+F 48 | Control Cohort M+F 58 | p Value* | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Males (n = 30)
|
Females (n = 18)
|
Males (n = 36)
|
Females (n = 22)
|
||||||||
| n | % | n | % | n | % | n | % | ||||
| Born <1950 | 2 | 6 | 1 | 5 | 25 | 69 | 19 | 86 | 3 | 44 | <0.0001 |
| Born ≥1950 | 28 | 93 | 17 | 95 | 11 | 31 | 3 | 14 | 45 | 14 | |
| Methods of diagnosis | |||||||||||
| Obligate carrier (OC) | 4 | 13 | 4 | 50 | 18 | 51 | 17 | 49 | 8 | 35 | <0.0001 |
| DNA haplotype | 22 | 74 | 14 | 39 | 5 | 50 | 5 | 50 | 36 | 10 | <0.0001 |
| Clinical event (SCD or VT) | 4 | 13 | 0 | 0 | 13 | 10 | 0 | 0 | 4 | 13 | <0.05 |
| Mean age at entry (yrs) | 33.3 | 40.3 | 32.2 | 40 | ns | ||||||
| Median age at entry (yrs) | 32.9 | 42 | 32.7 | 39.2 | ns | ||||||
| Standard deviation (yrs) | 9.8 | 9.0 | 9.6 | 9.5 | ns | ||||||
*
Chi-square with 1 df for ICD M+F vs. control M+F.
ARVC = arrhythmogenic right ventricular cardiomyopathy; ICD = implantable cardioverter-defibrillator; SCD = sudden cardiac death; VT = ventricular tachycardia.