Figure 1.
A. Immunohistochemistry of a paraffin-embedded C57BL/6J mouse retinal section bleached with H2O2/formamide and stained with hematoxylin and an antibody directed against Mertk. Prominent staining is evident in the apical area of the RPE (arrow), above the RPE nuclei. GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; OS, outer segment; RPE, retinal pigment epithelium. B. Protein domain structure of human MERTK. Numbers within the colored boxes indicate the extent of each domain (UniProt Database). Positions of key phosphotyrosine residues involved in MERTK signaling are indicated to the left.