Table 1.
Descriptive statistics of all patients (single and multiple vasopressor; n = 114) data as median ± SEM and percentage
| Single vasopressor (n = 101) |
Second vasopressor (n = 13) |
P | |
|---|---|---|---|
| Baseline characteristics | |||
| Age (years) | 40 ± 2 | 26 ± 4 | 0.29 |
| Male gender | 78% | 77% | 1 |
| Weight (kg) | 77 ± 2 | 83 ± 6 | 0.79 |
| ICU GCS | 3 ± 0 | 3 ± 0 | 1 |
| ISS | 35 ± 1 | 43 ± 5 | 0.14 |
| Head AIS | 5 ± 0 | 5 ± 0 | 0.17 |
| Polytrauma | 70% | 61% | 0.54 |
| Fluid balance and blood products requirement during 3 h before and 3 h after VP started | |||
| Fluid balance (ml/kg) | 8 ± 2 | 8.5 ± 2 | 0.84 |
| % Blood products requirement | 21% | 70% | 0.001 |
| Number of RBC units transfused | 0 ± 0 | 3 ± 0 | 0.001 |
| Physiologic data | |||
| HR at 3 h, bpm (n = 112) | 93 ± 2 (N = 99) | 120 ± 8 (N = 13) | 0.001 |
| MAP at 3 h, mmHg (n = 114) | 81 ± 1 (N = 101) | 78 ± 5 (N = 13) | 0.18 |
| ICP at 3 h, mmHg (n = 61) | 17 ± 2 (N = 58) | 16 ± 7 (N = 3) | – |
| CPP at 3 h, mmHg (n = 59) | 66 ± 2 (N = 56) | 48 ± 20 (N = 3) | – |
| PbtO2 at 3 h, mmHg (n = 6) | 20 ± 3 (N = 5) | 11 (N = 1) | – |
| In-hospital mortality | 55% | 85% | 0.07 |
ICU GCS GCS score at the intensive care unit admission, ISS Injury severity score, Head AIS Head Abbreviated Injury Scale Score, HR heart rate (bpm), MAP mean arterial pressure (mmHg), ICP intracranial pressure (mmHg), CPP cerebral perfusion pressure (mmHg), PbtO2 brain tissue oxygenation (mmHg)