Table 2.
Effect of bolus injection of 5-fluorouracil (5-FU) on the plasma concentration of uracil (ng/mL) in the CPT-11 + 5-FU/LV + UFT/LV chemotherapy a)
| Time (hr) | 5-FU dosing | with bolus injection of 5-FU (N = 5) | without bolus injection of 5-FU (N = 5) | P |
|---|---|---|---|---|
| 0 | 1st oral UFT/LV | 22.6±19.3 | 10.1±19.6 | NS |
| 0.5 | 1429.6±3133.5 | 26.6±41.6 | NS | |
| 1 | 983.9±1112.2 | 660.2±704.4 | NS | |
| 2 | 381.9±277.0 | 2169.6±2124.2 | NS | |
| 2.5 | bolus injection b) | 579.6±916.7 | 2031.7±2070.5 | NS |
| 2.75 | 287.7 (2450.3) | 622.0 (4232.1) | NS | |
| 3 | 325.1 (3447.7) | 224.6 (944.2) | NS | |
| 3.5 | 765.7±1207.9 | 66.7±94.0 | NS | |
| 4 | 137.9 (647.3) | 24.2 (41.8) | <0.05 | |
| 8 | 2nd oral UFT/LV | 53.1±9.8 | 22.9±29.1 | NS |
| 10 | 415.6±333.2 | 271.6±240.5 | NS | |
| 24 | 4th oral UFT/LV | 37.6±5.5 | 17.1±20.0 | NS |
| 48 | 7th oral UFT/LV | 30.9 (13.4) | 5.0 (25.9) | NS |
| 336 | 19.8±15.5 | 1.4±1.9 | NS |
The values are the mean±SD, when the normality assumption held, and are medians with interquartile ranges in parentheses, when failed.
a) Protocol is indicated in Figure 1. “Time 0” means 9:00 on day 1, the time of the first oral administration of UFT/LV at 100 mg x 3 as tegafur/m2/day and 25 mg x 3/day, respectively. The intravenous infusion of CPT-11 at 100 mg/m2 was done from Time = 0.5 hr to 2 hr, and followed by the infusion of l-LV at 15 mg/m2 for 30 min. Immediately thereafter, a bolus of 5-FU was injected at a dose of 500 mg/m2.
b) Five of 10 patients were not injected with a bolus of 5-FU.