Table 3.
Effect of bolus injection of 5-fluorouracil (5-FU) on the plasma concentration of tegafur (ng/mL) in the CPT-11 + 5-FU/LV + UFT/LV chemotherapy a)
| Time (hr) | 5-FU dosing | with bolus injection of 5-FU (N = 5) | without bolus injection of 5-FU (N = 5) | P |
|---|---|---|---|---|
| 0 | 1st oral UFT/LV | 0.0±0.0 | 0.0±0.0 | NS |
| 0.5 | 938.7 (4028.0) | 548.1 (1243.7) | NS | |
| 1 | 3456.2±2299.1 | 2669.5±2003.5 | NS | |
| 2 | 5453.3±2282.2 | 6394.3±2478.1 | NS | |
| 2.5 | bolus injection b) | 5571.8±1512.6 | 6770.0±1697.6 | NS |
| 2.75 | 5667.8±1305.9 | 6600.0±1611.4 | NS | |
| 3 | 5498.1±1246.9 | 6233.5±1621.3 | NS | |
| 3.5 | 4783.9±1528.9 | 5574.5±1313.9 | NS | |
| 4 | 5129.5±1339.3 | 4897.0±1607.2 | NS | |
| 8 | 2nd oral UFT/LV | 3556.0±1111.4 | 3292.4±1007.6 | NS |
| 10 | 7040.0±1721.2 | 7093.6±2711.9 | NS | |
| 24 | 4th oral UFT/LV | 3932.4±1042.7 | 3094.1±867.6 | NS |
| 48 | 7th oral UFT/LV | 5090.8±1794.3 | 4167.7±1639.4 | NS |
| 336 | 0.0±0.0 | 0.0±0.0 | NS |
The values are the mean±SD, when the normality assumption held, and are medians with interquartile ranges in parentheses, when failed.
a) Protocol is indicated in Figure 1. “Time 0” means 9:00 on day 1, the time of the first oral administration of UFT/LV at 100 mg x 3 as tegafur/m2/day and 25 mg x 3/day, respectively. The intravenous infusion of CPT-11 at 100 mg/m2 was done from Time = 0.5 hr to 2 hr, and followed by the infusion of l-LV at 15 mg/m2 for 30 min. Immediately thereafter, a bolus of 5-FU was injected at a dose of 500 mg/m2.
b) Five of 10 patients were not injected with a bolus of 5-FU.