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Area under the plasma concentration-time curve from 0 hr to 48 hr (AUC0-48) of uracil, 5-fluorouracil (5-FU) and tegafur in patients treated with the CPT-11 + 5-FU/LV + UFT/LV chemotherapy
| AUC0-48 (mg*h/L) | uracil | 5-FU | tegafur |
|---|---|---|---|
| with bolus injection of 5-FU | 8.50±3.68 | 22.16±6.57 | 227.83±50.91 |
| without bolus injection of 5-FU | 6.17±2.49 | 0.65±0.42 * | 202.98±61.46 |
The values are the mean±SD.
* P < 0.05, compared with the data obtained with bolus injection of 5-FU.
