Figure 6. Resolution circuitry.
(A) Scheme of RvD1 miRNA circuit. RvD1 is generated within inflammatory exudates and acts directly on selective cell types such as monocytes/macrophages. RvD1 actions are via its receptors, ALX or GPR32 to regulate miRNAs, transcription factors, gene expression and cellular function. (B) RvD1 down-regulates miR-219 via its receptors ALX and GPR32, which leads to less 5-LOX protein (C) and reduced LTB4 generation (D). Adapted from [99]. *P<0.05 compared against vehicle; #P<0.05 compared against mock.