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. 2011 Jun 28;437(Pt 2):185–197. doi: 10.1042/BJ20110327

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© 2011 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Scheme of RvD1 miRNA circuit. RvD1 is generated within inflammatory exudates and acts directly on selective cell types such as monocytes/macrophages. RvD1 actions are via its receptors, ALX or GPR32 to regulate miRNAs, transcription factors, gene expression and cellular function. (B) RvD1 down-regulates miR-219 via its receptors ALX and GPR32, which leads to less 5-LOX protein (C) and reduced LTB₄ generation (D). Adapted from [99]. *P<0.05 compared against vehicle; ^#P<0.05 compared against mock.