Figure 2. Amino acid alignment of ortholog ICP0 RING-finger domains from HSV-1, HSV-2, bovine herpes virus type-1, equine herpes virus type-1, pseudorabies virus and varicella zoster virus.
Gray vertical bars highlight conserved cysteine and histidine residues within the C3HC4 RING domain that co-ordinate the binding of two zinc atoms. Bracketed numbers refer to the amino acid positions of the first and last amino acid in each alignment with respect to their parental polypeptide sequences.
ICP0: Infected cell protein 0; RING: Really interesting new gene.