Table 1.
Gravimetric measurements of control sham, AVF, HHcy, AVF+HHcy mice treated with or without MK-801. Body weight (BW) in grams and heart weight (HW) in mgare reported. Plasma levels of Hcy and mitochondria ONOO- and numbers of premature ventricle contraction (PVC) are presented
| BW, g | HW, mg | HW/BW, mg/g | Hcy, µMole/L | mtONOO- nMole/L | Number PVC/min | |
|---|---|---|---|---|---|---|
| Sham | 25+1 | 161+10 | 6.44+0.9 | 5+1 | 10+2 | 0 |
| AVF | 24+1 | 188+11 | 7.83+0.75* | 7+1 | 60+4* | 2-5 |
| HHcy | 23+1 | 174+9 | 7.57+0.8* | 28+2* | 40+3* | 1-2 |
| AVF+HHcy | 26+1 | 192+12 | 7.38+0.7* | 32+3* | 90+8* | 10-15* |
| Sham+MK | 25+1 | 160+13 | 6.40+0.9 | 4+1 | 10+1 | 0 |
| AVF+MK | 24+1 | 166+12 | 6.92+1.1 | 7 + 1 | 25+3 | 1-2 |
| HHcy+MK | 26+1 | 165+14 | 6.35+0.6** | 25+2 | 20+2* | * 1-2 |
| AVF+HHcy+MK | 25+1 | 170+15 | 6.80+0.75 | 26+3 | 60+5 | 3-5*** |
Values are mean+SEM of 10 animals.
*
p<0.05 vs sham
**
p<0.05 vs HHcy
***
P<0.05 vs HHcy or AVF.