Table II. List of differently expressed glycoproteinsa found with quantitative proteomics method in human serum of patients with hepatocellular carcinoma.
| IPI Number | Swiss-prot | Protein Name | SpCb_Cancer | SpC_Normal |
|---|---|---|---|---|
| IPI00004573 | P01833 | Polymeric-immunoglobulin receptor | 6.5 | NDc |
| IPI00007240 | P05160 | Coagulation factor XIII B chain | 8 | 16.5 |
| IPI00008556 | P03951 | Splice Isoform 1 of Coagulation factor XI | 1 | 5.5 |
| IPI00009793 | Complement component 1, r subcomponent-like variant (Fragment) | 2.5 | 7 | |
| IPI00010295 | P15169 | Carboxypeptidase N catalytic chain | 17.5 | 7 |
| IPI00018305 | P17936 | Insulin-like growth factor-binding protein 3 | 3 | 7 |
| IPI00021857 | P02656 | Apolipoprotein C-III | 16 | 81.5 |
| IPI00021891 | P02679 | Splice Isoform Gamma-B of Fibrinogen gamma chain | 20 | ND |
| IPI00022295 | P10720 | Platelet factor 4 variant | ND | 4 |
| IPI00022394 | P02747 | Complement C1q subcomponent subunit C | 21.5 | 12.5 |
| IPI00022443 | P02771 | Alpha-fetoprotein | 76.5 | 0.5 |
| IPI00022731 | P55056 | Apolipoprotein C-IV | 1 | 4.5 |
| IPI00023014 | P04275 | Von Willebrand factor | 33 | 9.5 |
| IPI00023673 | Q08380 | Galectin-3-binding protein | 21.5 | 6.5 |
| IPI00025864 | P06276 | Cholinesterase | 1.5 | 6.5 |
| IPI00027410 | P40197 | Platelet glycoprotein V | ND | 4.5 |
| IPI00027507 | Q02985 | Complement factor H-related protein 3 | 9 | ND |
| IPI00029193 | Q04756 | Hepatocyte growth factor activator | 1 | 7.5 |
| IPI00029260 | P08571 | Monocyte differentiation antigen CD14 | 16 | 7 |
| IPI00029717 | P02671 | Splice Isoform 2 of Fibrinogen alpha chain | 19.5 | 4 |
| IPI00030739 | O95445 | Apolipoprotein M | 5 | 11.5 |
| IPI00031411 | Q14517 | Cadherin-related tumor suppressor homolog | ND | 4.5 |
| IPI00064667 | Q96KN2 | Glutamate carboxypeptidase-like protein 2 | 3 | 11 |
| IPI00186903 | O14791 | Splice Isoform 2 of Apolipoprotein-L1 | 6 | 15.5 |
| IPI00215894 | P01042 | Splice Isoform LMW of Kininogen-1 | 47 | 112 |
| IPI00218413 | P43251 | biotinidase | 5 | 11.5 |
| IPI00291262 | P10909 | Clusterin | 38 | 82 |
| IPI00296099 | P07996 | Thrombospondin-1 | 7.5 | 23.5 |
| IPI00296176 | P00740 | Coagulation factor IX | 4.5 | 12 |
| IPI00298497 | P02675 | Fibrinogen beta chain | 10.5 | ND |
| IPI00298860 | P02788 | Growth-inhibiting protein 12 | 2 | 10.5 |
| IPI00298971 | P04004 | Vitronectin | 56.5 | 115 |
| IPI00299307 | P48740 | Complement-activating component of Ra-reactive factor | 2.5 | 5.5 |
| IPI00299503 | P80108 | Phosphatidylinositol-glycan-specific phospholipase D 1 | 6.5 | 14 |
| IPI00385264 | P04220 | Ig mu heavy chain disease protein | 194.5 | 94.5 |
| IPI00385509 | Q15127 | Phosphatidylinositol-glycan-specific phospholipase D 2 | ND | 9.5 |
| IPI00478809 | P12259 | Coagulation factor V | 2.5 | 8 |
| IPI00639937 | P00751 | Complement factor B | 137.5 | 68 |
a Proteins were confirmed as glycoproteins by identification of N-glycopeptides in this study and previous large-scale studies of human liver N-glycoproteome (21).
b The spectral counting was the average of spectral counts of three replicated LC-MS/MS runs.
c ND denotes no mass spectra matched to this protein in this sample set.