Table III. Enrichment analysis of Gene Ontogeny (GO) component predictions of serodiagnostic antigens. The 115 serodiagnostic IgG and IgM antigens (126 exon hits) identified in this study were analyzed for enrichment against full genome as described in the text. GO component predictions were obtained from ToxoDB.org. Significant fold enrichment, or underrepresentation for certain features, are underlined and bold.

GO Component Predictions	Proteins in Category	Exons on Chip	Serodiagnostic
			Exon Hits	Gene Hits	FoldEnrich	p value
GO Cytoskeleton and organization	28	4	0	0	0.0	1.000
GO Chromosome	19	13	0	0	0.0	1.000
GO ER and Golgi network	34	41	3	2	4.2	0.083
GO Intracellular	272	49	3	3	0.8	1.000
GO Extracellular	28	5	0	0	0.0	1.000
GO Mitochondria	30	10	1	1	2.4	0.347
GO Membrane associated	381	260	35	30	5.6	4.079E-15
GO Motor proteins	18	18	0	0	0.0	1.000
GO Protease complex	22	7	2	2	6.4	0.038
GO signal recognition complex	8	6	0	0	0.0	1.000
GO Other Cytoplasm, nucleus or nuclear pore	236	62	5	5	1.5	0.389
Other GO components	78	16	0	0	0.0	0.630
GO component Null	7001	876	77	72	0.7	3.876E-10
Total GO component	8155	1367	126	115