Figure 1.
Preventing C-terminal modification of p53 engenders exquisite radiosensitivity, particularly in the hematopoietic system. (A) Kaplan-Meier radiation survival curves in WT mice and p537KR (7KR) mice after 4, 5, and 6 Gy of whole-body irradiation showing dose-dependent mortality in p537KR mice (4 Gy: n = 58, P < 0.001; 5 Gy: n = 25, P < 0.001; 6 Gy: n = 10, P < 0.001). (B) Increased cardiac weights and enlarged hearts in irradiated p537KR mice 4 wk after 5 Gy of irradiation. Error bars represent the SEM from four animals. The representative hearts from nonirradiated and irradiated mice are shown in the picture. (C) H&E staining of thymus, spleen, and BM from a p537KR mouse that died after exposure to 5 Gy of whole-body irradiation.