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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Hum Mutat. 2011 Mar;32(3):318–324. doi: 10.1002/humu.21439

Fig 2. Cytokine production, NEMO protein expression, and NF-κB binding activity in dendritic cells with deleted or mutated zinc finger domain.

Fig 2

(A) TNFα and (B) IL-12 production in patient monocytes after LPS/IFN-γ treatment. Open bar, normal; closed and hatched bars, two E391X siblings and two experiments on the same C417R patient. (C) Western analysis of NEMO protein in PBMCs. (D) EMSA analysis of NF-κB binding activity in DCs of two E391X siblings and C417R patient after LPS treatment. Fold inductions were quantitated using ImageJ software normalized by Sp1.