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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Hum Mutat. 2011 Mar;32(3):318–324. doi: 10.1002/humu.21439

Fig 3. An intact NEMO ZF domain is more important than its polyubiquitination for full activation of MAPK in LPS-treated dendritic cells.

Fig 3

Western blot analysis of MAPK activities in DCs from patients with the C417 missense mutation (A) and the E391X ZF deletion (B) after LPS treatment. Polyubiquitination of NEMO in E391X ZF deleted (C) and C417R missense (D) patients after LPS stimulation. (E) Bone marrow derived macrophages from NEMO K392R mice were stimulated with LPS and MAPK activities were analyzed by western blot.