Table 1.
Summary of transcription factor expression in the dentate gyrus.
Transcription Factor |
Expression Pattern |
Type of Study and Stage of Development |
References |
---|---|---|---|
Pax6 | Type-1 and type-2a cells |
Expression (postnatal and adult) Loss of function (postnatal) |
Maekawa et al., 2005
Nacher et al., 2005 Hodge et al., 2008 Roybon et al., 2009 |
Tbr2 | Type-2b and type-3 cells |
Expression (adult) Loss of function (embryonic conditional null mutant) |
Arnold et al., 2008
Hodge et al., 2008 Roybon et al., 2009 |
Tbr1 | Immature neurons and mature neurons |
Expression (adult) |
Hodge et al., 2008
Roybon et al., 2009 |
Sox2 | Type-1 and type-2a cells |
Expression (adult) Loss of Function (embryonic null mutant) Loss of function (adult inducible conditional knockout) |
Eriksson, 2004 Ferri et al., 2004 Komitova and Suh et al., 2007 Favaro et al., 2009 Kuwabara et al., 2009 Ehm et al., 2010 Lugert et al., 2010 |
Sox3 | Type-3 cells and immature neurons |
Expression (adult) | Wang et al., 2006 |
Sox11 | Type-3 cells and immature neurons |
Expression (adult) Gain of function (in vitro overexpression) |
Haslinger et al., 2011 |
Hes5 | Type-1 cells | Expression (adult) | Lugert et al., 2010 |
Ascl1 | Type-1 and type-2a cells |
Expression (adult) Lineage tracing (adult) Gain of function (retroviral overexpression in vivo) |
Kim et al., 2007
Hodge et al., 2008 Roybon et al., 2009 |
Neurog2 | Type-2a and type- 2b cells |
Expression (postnatal, adult) Loss of function (postnatal) Gain of function (postnatal retroviral overexpression) |
Ozen et al., 2007
Hodge et al., 2008 Roybon et al., 2009 |
NeuroD1 | Type-2b, type-3, and immature neurons |
Expression (postnatal, adult) Loss of function (embryonic null mutant) Loss of function (adult conditional knockout) |
Lee et al., 2000
Liu et al., 2000 Schwab et al., 2000 Seki, 2002 Del Turco et al., 2004 Seri et al., 2004 Hodge et al., 2008 Gao et al., 2009 Kuwabara et al., 2009 Roybon et al., 2009 |
NPAS3 | Not determined | Loss of function (embryonic null mutant) |
Pieper et al., 2005 |
FoxG1 | Type-2 and type-3 cells |
Loss of function (postnatal) |
Shen et al., 2006
Eagleson et al., 2007 |
Prox1 | Type-3 cells, immature and mature neurons |
Expression (postnatal, adult) Loss of function (postnatal and adult conditional knockout) |
Lavado and Oliver, 2007
Lavado et al., 2010 |
CREB | Immature neurons | Expression (adult) Loss of function (adult) Gain of function (adult) |
Nakagawa et al., 2002a, b Fujioka et al., 2004 Jagasia et al., 2009 |