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Self-regulating, individualized inflammation-modulating bioreactor. Plasmids consisting of cytokine-sensitive promoters upstream of endogenous cytokine inhibitors have been constructed using standard molecular biology techniques. The plasmids have been transfected into hepatocyte cell lines. The cells are seeded into bioreactors. In the future, such bioreactors could be connected extracorporeally in order to modulate inflammation in a disease- and patient-specific manner.
